CHLORCHIP (MXBIO INC.)
ChlorChip is a small, rectangular chip that can be inserted into a periodontal pocket to slow down gum recession with periodontal disease.
ChlorChip is made of biodegradable gelatin nanofibers with the antiseptic agent ( 2.5 mg of chlorhexidine gluconate).
When the ChlorChip is inserted into the patient’s periodontal pocket by a dentist, the nanofibers will slowly degrade by interacting with periodontal crevicular fluid.
The chlorhexidine in the nanofibers is continuously released over the next 7 to 8 days until the degradation process is completed and the ChlorChip will disappear.
Periodontal gum disease-causing bacteria will be eliminated by the ChlorChip during the treatment period and the patient’s periodontal pocket depth will be reduced.
PRODUCT FEATURES
Use of electrospun nanofiber : High biodegradability
The strongest technological upgrade for the ChlorChip is the electrospun gelatin nanofibers.
The diameter of the electrospun nanofibers is around 200 – 350 nm, which creates porous surfaces and thus granting the ChlorChip much more surface area.
The specialized surface structure of the ChlorChip allows for a much higher biodegradability in the patient’s periodontal pocket versus other competitive products.
No use of cross-linking agents: High biocompatibility
Usually, biodegradable polymers are used for the Drug Delivery System (DDS) and cross-linking agents are also used as additive to prevent that polymer from dissolving in unintended time.
Glutaraldehyde is a well known cross-linking agent.
Even if it is used in a very tiny amount, it still carries a potential for toxicity.
In addition, a reduction of biodegradability of the chip can be attributed to this cross-linking agent.
To remove the potential risks of Glutaraldehyde (Toxicity and Decrease in Biodegradability), no cross-linking agent will be used in the manufacturing of the ChlorChip.
